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Inhibition of the TLR4/NF-κB/TNF-α axis by TAK-242 or PDTC reduces central nervous system inflammation to alleviate lipopolysaccharide induced sickness behaviors in mice

2022-03-23

Abstract excerpt

<h4>Background: </h4> During the pathogenic microorganisms infection, animals will exhibit sickness behaviors, yet there is a lack of sufficient research on the pathogenesis of sickness behaviors and related treatments. We aim to ascertain the molecular mechanisms of lipopolysaccharide (LPS)-induced sickness behaviors and to find potential therapeutic methods. <h4>Methods: </h4>: In this study, the mice with sickn...

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Literature Corpus work
db00897c-9e2a-5b26-85b0-e0f799751fd4
DOI
10.21203/rs.3.rs-1471486/v1
Open publication

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Inhibition of the TLR4/NF-κB/TNF-α axis by TAK-242 or PDTC reduces central nervous system inflammation to alleviate lipopolysaccharide induced sickness behaviors in miceDOI 10.21203/rs.3.rs-1471486/v1
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