Back to search

Article

Germacrone attenuates memory impairment, hippocampal inflammation, and neurological deficits induced by Lipopolysaccharide in mice

2024-01-04

Abstract excerpt

<h4>Background: </h4> Uncontrolled neuroinflammation contributes to a range of neurodegenerative diseases, as such targeting neuroinflammation may be a promising therapeutic strategy. Germacrone (GE) is the primary ingredient of Curcumae Wenyujin Y.H. Chenet C Ling , one of the most commonly used traditional Chinese medicine boasting anti-inflammatory pharmacology effects. However, there are no reports related to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
435703aa-7a39-5889-9787-a23f2f7368e2
DOI
10.21203/rs.3.rs-3825950/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Germacrone attenuates memory impairment, hippocampal inflammation, and neurological deficits induced by Lipopolysaccharide in miceDOI 10.21203/rs.3.rs-3825950/v1
Inhibition of the TLR4/NF-κB/TNF-α axis by TAK-242 or PDTC reduces central nervous system inflammation to alleviate lipopolysaccharide induced sickness behaviors in miceSemantic proximity
Crocin improves cognitive impairment in LPS-treated rats by anti-apoptotic, anti-inflammatory and antioxidant activitiesSemantic proximity
4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice.Semantic proximity
Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout miceSemantic proximity
Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammationSemantic proximity
Ameliorative Effects of Arctigenin From Arctium Lappa L Against LPS-induced Neuroinflammation and Cognitive Impairments in MiceSemantic proximity
Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current LiteratureSemantic proximity
Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice.Semantic proximity
PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4Semantic proximity
Qiang Xin 1 Formula Suppresses Excessive Pro-inflammatory Cytokine Responses and Microglia Activation to Prevent Cognitive Impairment and Emotional Dysfunctions in Experimental SepsisSemantic proximity
Naringenin Ameliorates LPS-Induced Neuroinflammation Through NF-κB Signaling in Human Microglia and Protects Neuronal CellsSemantic proximity
Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in Lipopolysaccharide-induced neuroinflammationSemantic proximity
Select a neighboring publication to make it the new centre.