Article

Diazoxide/dibenozylmethane treatment mitigates spatial memory deficits and pathology and upregulates protective genes in an Alzheimer’s transgenic rat model

2023-09-05

Abstract excerpt

<h4>INTRODUCTION</h4> Alzheimer’s disease (AD) is a multifactorial disease for which therapeutic efficacy should benefit from a multi-target approach. Thus, we evaluated a combined chronic treatment with diazoxide (DZ) and dibenzoylmethane (DIB). DZ is a potassium channel activator. DIB counteract eIF2α-P-driven stress responses. The individual therapeutic benefits of each drug on attenuating neurodegeneration an...

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Literature Corpus work: 6f09024f-f940-578e-ad8f-bb2e832229b8
DOI: 10.1101/2023.09.01.555966

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