Article

Alhydrogel TM , a widely used adjuvant, modulates multiple networks implicated in brain aging and has potential in the prevention of age-related cognitive decline

2026-05-25

Abstract excerpt

<title>Abstract</title> <bold>BACKGROUND:</bold> A preliminary efficacy trial in early Alzheimer’s Disease (AD) serendipitously revealed that Alhydrogel ® (alum) treated controls showed preservation of cognition, function, and hippocampal volume, with early onset and striking effect size. Aging is the highest risk factor for developing AD. We propose repurposing Alhydrogel ® , form...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27856455-c39b-5c67-9aa1-af7d8f03483c
DOI: 10.21203/rs.3.rs-9541548/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alhydrogel TM , a widely used adjuvant, modulates multiple networks implicated in brain aging and has potential in the prevention of age-related cognitive declineDOI 10.21203/rs.3.rs-9541548/v1Read

Age, Sex and Alzheimer’s disease: A longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patientsSemantic proximity Read

Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer’s disease mouse modelsSemantic proximity Read

A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer’s disease in aging miceSemantic proximity Read

Acarbose improves cognitive function in a mouse model of normal aging but not Alzheimer’s diseaseSemantic proximity Read

Divergence in the metabolome between natural aging and Alzheimer’s diseaseSemantic proximity Read

Maresin-like 1 Ameliorates Neuropathology of Alzheimer's Disease in Brains of a Transgenic Mouse ModelSemantic proximity Read

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brainSemantic proximity Read

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.Semantic proximity Read

Nanotechnology Therapy for Alzheimer's Disease Memory Impairment Attenuation.Semantic proximity Read

Multi-omics analysis reveals neuroinflammation, activated glial signaling, and dysregulated synaptic signaling and metabolism in the hippocampus of aged miceSemantic proximity Read

Isoflurane and surgery aggravate APOE4-dependent lipid dysregulation and neural dysfunction, leading to neurological impairment in male miceSemantic proximity Read

Beyond Symptom Management: FAAH Inhibition as a Path to Mitigate Alzheimer’s Disease Progression in Mouse Models of AmyloidosisSemantic proximity Read