Article

Optogenetic decoupling of ODC inhibition and degradation reveals a requirement of polyamine oscillation for cell cycle progression

2026-07-17

Abstract excerpt

The dysregulation of polyamine homeostasis is a fundamental hallmark of both cancer and aging. Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine synthesis, is regulated by the antizyme OAZ1 through a dual mechanism: inhibition of enzymatic activity and induction of proteasomal degradation via a C-terminal degron. In Bachmann-Bupp syndrome (BABS), mutations in this degron lead to ODC accumulation...

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Literature Corpus work: 9b1b249c-1434-5b3f-a6ac-22509c718ce2
DOI: 10.64898/2026.07.16.739060

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