Article
Autonomous Metabolic Oscillations Robustly Gate the Early and Late Cell Cycle.
Molecular cell - 19 Jan 2017
Papagiannakis Alexandros, Niebel Bastian, Wit Ernst C, Heinemann Matthias
Abstract excerpt
Eukaryotic cell division is known to be controlled by the cyclin/cyclin dependent kinase (CDK) machinery. However, eukaryotes have evolved prior to CDKs, and cells can divide in the absence of major cyclin/CDK components. We hypothesized that an autonomous metabolic oscillator provides dynamic triggers for cell-cycle initiation and progression. Using microfluidics, cell-cycle reporters, and single-cell metabolite...
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