Article

ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC

2024-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Over 95% of pancreatic ductal adenocarcinomas (PDAC) harbor oncogenic mutations in K-Ras. Upon treatment with K-Ras inhibitors, PDAC cancer cells undergo metabolic reprogramming towards an oxidative phosphorylation-dependent, drug-resistant state. However, direct inhibition of complex I is poorly tolerated in patients due to on-target induction of peripheral neuropathy. In this work, we develop...

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Literature Corpus work: 5242137d-65be-5413-a88e-02bd7c1b7537
DOI: 10.1101/2024.05.19.594824

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