Article

The polyol pathway is an evolutionarily conserved system for sensing glucose uptake

2021-09-16

Abstract excerpt

<h4>Summary</h4> Cells must adjust the expression levels of metabolic enzymes in response to fluctuating nutrient supply. For glucose, such metabolic remodeling is highly dependent on a master transcription factor ChREBP/MondoA. However, it remains elusive how glucose fluctuations are sensed by ChREBP/MondoA despite the stability of major glycolytic pathways. Here we show that in both flies and mice, ChREBP/Mondo...

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Literature Corpus work: 08019262-c31a-56df-b7ae-c72ac71c3a83
DOI: 10.1101/2021.09.14.460366

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