Article

Conserved lipid and small molecule modulation of COQ8 reveals regulation of the ancient UbiB family

2017-06-13

Abstract excerpt

<h4>Summary</h4> Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the biochemical activity of COQ8 and its direct role in CoQ production remain unclear, in part due to lack of known endogenous regulators of COQ8 function and of effective small molecules for probing its activity in vivo . Here w...

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Literature Corpus work: 36479ae0-833a-59ca-a359-61b914e9dbe3
DOI: 10.1101/149823

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