Article

Disruption of oncogenic targeting by ISWI via phosphorylation of a prion-like domain

2020-03-12

Abstract excerpt

<h4>Summary</h4> Chromosomal translocations generate oncogenic fusion proteins in approximately one-third of sarcomas, but how these proteins promote tumorigenesis and the effect of cancer therapies on their function are not well understood. Here, we reveal a molecular mechanism by which the fusion oncoprotein FUS-CHOP promotes tumor maintenance that also explains the remarkable radiation sensitivity of myxoid li...

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Literature Corpus work: 9afab03d-42cb-5d1b-91b1-8bbf3012748f
DOI: 10.1101/2020.03.11.987750

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