Article
Whole-Genome Sequencing Reveals Mutational Signatures Related to Radiation-Induced Sarcomas and DNA-Damage-Repair Pathways.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2023
Kim Eunji, Han Dong-Jin, Kim Byoung Hyuck, Yoo Jinseon, Kim Hak Jae, Wu Hong-Gyun, Kim Kyung Su, Kim Han-Soo, Han Ilkyu, Moon Kyung Chul, Park Jeong Hwan, Song Sanghyuk, Kim Tae-Min, Chang Ji Hyun
Abstract excerpt
Radiation-induced sarcoma (RIS) is a rare but serious late complication arising from radiotherapy. Despite unfavorable clinical outcomes, the genomic footprints of ionizing radiation in RIS development remain largely unknown. Hence, this study aimed to characterize RIS genomes and the genomic alterations in them. We analyzed whole-genome sequencing in 11 RIS genomes matched with normal genomes to identify somatic...
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