FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer

Abstract excerpt

<title>Abstract</title> <p>The genetic principle of synthetic lethality is clinically validated in cancers with loss of specific DNA damage response (DDR) pathway genes (i.e. BRCA1/2 tumor suppressor mutations). The broader question of whether and how oncogenes create tumor-specific vulnerabilities within DDR networks remains unanswered. Native FET protein family members are among the earliest proteins recruited...

Topics

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• Cancer Genomics and Diagnostics
• DNA Repair Mechanisms
• Lymphoma Diagnosis and Treatment
• PARP inhibition in cancer therapy
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Sarcoma Diagnosis and Treatment
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

098efa04-dd44-5812-94d8-8a56458ffd8d

DOI

10.21203/rs.3.rs-2869150/v1