Article

SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs Sarcomagenesis

2024-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Synovial Sarcoma (SySa) is an aggressive soft tissue sarcoma that accounts for 5 – 10% of all soft tissue sarcomas. Current treatment involves radiation and radical surgery including limb amputation, highlighting the urgent need to develop targeted therapies. We reasoned that transcriptional rewiring by the fusion protein SS18-SSX, the sole oncogenic driver in SySa, creates specific vulnerabilit...

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Literature Corpus work: bdc6fa2b-f6de-5d37-b941-00cc7af132b8
DOI: 10.1101/2024.09.23.614593

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