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Article

Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma

11 May 2023

Abstract excerpt

Amplification of MDM2 on supernumerary chromosomes is a common mechanism of P53 inactivation across tumors. Here, we investigated the impact of MDM2 overexpression on chromatin, gene expression, and cellular phenotypes in liposarcoma. Three independent regulatory circuits predominate in aggressive, dedifferentiated tumors. RUNX and AP-1 family transcription factors bind mesenchymal gene enhancers. P53 and MDM2...

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PMID: 37492096
DOI: 10.1016/j.xgen.2023.100321

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