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Article

Genomic Insights Into High-Grade Infarct-Associated Bone Sarcomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2024

Tvrdik Tatiana, Gjeorgjievski Sandra Gjorgova, Wong Philip, Oskouei Shervin, Read William, Bahrami Armita

Abstract excerpt

Sarcomas rarely develop in bones previously compromised by infarcts. These infarct-associated sarcomas often present as undifferentiated pleomorphic sarcomas (UPS), and their genetic characteristics are poorly understood. High-grade UPS of bone are typically treated with a combination of surgery and chemotherapy, similar to osteosarcoma. We conducted a detailed clinicopathologic and genomic analysis of 6 cases of...

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Source

Identifiers

PMID: 39033963
DOI: 10.1016/j.modpat.2024.100572

Genes

CDKN2A
TP53
DNMT3A
HRAS
MDM2
NF2
PIK3CA
POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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