Article

Multidimensional Characterization of Soft-Tissue Sarcomas with FUS-TFCP2 or EWSR1-TFCP2 Fusions

2023-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Linking clinical multi-omics analyses with mechanistic studies provides opportunities to explore the pathogenesis of rare cancers. We leveraged two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective systemic therapies. All tumors exhibited outlier expression of the ALK receptor tyrosine kinase, which was partly accompa...

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Literature Corpus work: 95e5bcb6-8242-5d6d-ab6b-198e66d055da
DOI: 10.1101/2023.02.19.528670

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