Article
Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities.
The Journal of pathology - 1 Apr 2018
McBride Matthew J, Kadoch Cigall
Abstract excerpt
Soft-tissue sarcomas are increasingly characterized and subclassified by genetic abnormalities that represent underlying drivers of their pathology. Hallmark tumor suppressor gene mutations and pathognomonic gene fusions collectively account for approximately one-third of all sarcomas. These gene...
Topics
- Animals
- Chromatin Assembly and Disassembly
- Chromosomal Proteins, Non-Histone
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Humans
- Phenotype
- Polycomb-Group Proteins
- Prognosis
- Sarcoma
- Soft Tissue Neoplasms
- Transcription Factors
- Transcription, Genetic