Biology and Therapy of Dominant Fusion Oncoproteins Involving Transcription Factor and Chromatin Regulators in Sarcomas

Abstract excerpt

A third of soft tissue sarcomas have been shown to carry recurrent, characteristic chromosomal translocations, many of which generate fusion proteins that act as dominant transcription factors or as chromatin regulators. With routine use of massively parallel sequencing and advances in technology for the study of epigenetics and protein complexes, the last decade has seen a marked advancement in the identification...

Topics

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• Protein Degradation and Inhibitors
• Sarcoma Diagnosis and Treatment
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

6cb68987-510c-5deb-b26a-6c7b2caf282b

DOI

10.1146/annurev-cancerbio-030518-055710