Article

Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components

2022-12-08

Abstract excerpt

In terms of its relative frequency, lysine is a common amino acid in the human proteome. However, by bioinformatics we find hundreds of proteins that contain long and evolutionarily conserved stretches completely devoid of lysine residues. These so-called lysine deserts show a high prevalence in intrinsically disordered proteins with known or predicted functions within the ubiquitin-proteasome system (UPS), includ...

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Literature Corpus work: 368fd07d-d091-53d9-b4f0-dfd1773eed31
DOI: 10.1101/2022.12.08.519562

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