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Article

Identification of mammalian protein quality control factors by high-throughput cellular imaging.

PloS one - 1 Jan 2012

Pegoraro Gianluca, Voss Ty C, Martin Scott E, Tuzmen Pinar, Guha Rajarshi, Misteli Tom

Abstract excerpt

Protein Quality Control (PQC) pathways are essential to maintain the equilibrium between protein folding and the clearance of misfolded proteins. In order to discover novel human PQC factors, we developed a high-content, high-throughput cell-based assay to assess PQC activity. The assay is based on a fluorescently tagged, temperature sensitive PQC substrate and measures its degradation relative to a temperature...

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Identifiers

PMID: 22363705
DOI: 10.1371/journal.pone.0031684
PMCID: PMC3282772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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