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Article

Exploring the "misfolding problem" by systematic discovery and analysis of functional-but-degraded proteins.

Molecular biology of the cell - 1 Dec 2023

Flagg Matthew P, Lam Breanna, Lam Darren K, Le Tiffany M, Kao Andy, Slaiwa Yousif I, Hampton Randolph Y

Abstract excerpt

In both health and disease, the ubiquitin-proteasome system (UPS) degrades point mutants that retain partial function but have decreased stability compared with their wild-type counterparts. This class of UPS substrate includes routine translational errors and numerous human disease alleles, such as the most common cause of cystic fibrosis, ΔF508-CFTR. Yet, there is no systematic way to discover novel examples of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37729018
DOI: 10.1091/mbc.E23-06-0248
PMCID: PMC10848938

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