Article

Systematic characterization of indel variants using a yeast-based protein folding sensor

2024-07-11

Abstract excerpt

Gene variants resulting in insertions or deletions of amino acid residues (indels) have important consequences for evolution and are often linked to disease, yet compared to missense variants the effects of indels are poorly understood and predicted. To approach this issue, we developed a sensitive protein folding sensor based on complementation of uracil auxotrophy in yeast by circular permutated orotate phosphor...

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Literature Corpus work: 388eabd4-54cd-5589-acc2-98a8e0f2b6b2
DOI: 10.1101/2024.07.11.603017

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