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Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity

2025-02-05

Abstract excerpt

<h4>ABSTRACT</h4> The standard of care in high-grade gliomas has remained unchanged in the past 20 years. Efforts to replicate effective immunotherapies in non-cranial tumors have led to only modest therapeutical improvements in glioblastoma (GB). Here, we demonstrate that intratumoral administration of recombinant interleukin-12 (rIL-12) promotes local cytotoxic CD8 POS T cell accumulation and conversion into a...

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Identifiers and source

Literature Corpus work
9ae7afe8-2d59-5255-a63f-223e676acb04
DOI
10.1101/2025.02.03.636330
Open publication

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Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunityDOI 10.1101/2025.02.03.636330
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