Article

Systemic viral vector vaccination induces brain resident memory T cells to drive anti-glioblastoma immunity

2026-06-20

Abstract excerpt

Glioblastoma is a lethal brain tumor that is unresponsive to current cancer immunotherapeutic approaches, including immune checkpoint blockade (ICB). This suggests that initial priming of T cells, rather than their expansion and licensing as effectors, is a restricting feature in this tumor setting. To overcome the limited initiation of CD8 + T cell responses, we employed a strong heterologous prime-boost vaccina...

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Literature Corpus work: 309b1b12-8c04-5acd-9946-8f2c75ecac81
DOI: 10.64898/2026.06.18.733241

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