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Article

Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity

21 Aug 2025

Abstract excerpt

T cells are functionally suppressed in the tumor microenvironments (TME) of de novo and recurrent glioma patients, we tested whether anti-tumor response at the rIL-12-inflamed tumor site could be enhanced with 4-1BBL, the ligand of 4-1BB. 4-1BBL was delivered using an adeno-associated virus (AAV) vector targeting GFAP-expressing cells and resulted in prolonged survival of rIL-1 2-treated GB-bearing mice. This...

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PMID: 40842154
DOI: 10.1016/j.ymthe.2025.08.028

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