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Article

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

29 Mar 2013

Abstract excerpt

Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 have been isolated from HIV-1-infected individuals; however, such bNAbs have not been induced by vaccination. Wild-type gp120 proteins lack detectable affinity for predicted germline precursors of VRC01-class bNAbs, making them poor...

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PMID: 23539181
DOI: 10.1126/science.1234150

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