Article

MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression

2019-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Reactive oxygen species (ROS) oxidise nucleotide triphosphate pools (e.g., 8-oxodGTP), which may kill cells if incorporated into DNA. Whether cancers avoid poisoning from oxidised nucleotides by preventing incorporation via the oxidised purine diphosphatase MTH1 remains under debate. Also, little is known about DNA polymerases incorporating oxidised nucleotides in cells or how oxidised nucleotid...

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Literature Corpus work: 9a9e5f0d-6090-5e22-a3c0-4011cc21a4df
DOI: 10.1101/573931

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