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Article

Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.

Cell cycle (Georgetown, Tex.) - 15 Mar 2012

Markkanen Enni, Hübscher Ulrich, van Loon Barbara

Abstract excerpt

Reactive oxygen species (ROS) constantly attack DNA. One of the best-characterized oxidative DNA lesions is 7,8-dihydro-8-oxoguanine (8-oxo-G). Many human diseases, such as cancer and neurodegenerative disorders, have been correlated with oxidative DNA damage. In the last few years, DNA polymerase (Pol) λ, one of the 15 cellular Pols, has been identified to play an important role in performing accurate...

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Identifiers

PMID: 22370481
DOI: 10.4161/cc.11.6.19448

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