Article

Telomeric 8-Oxoguanine Drives Rapid Premature Senescence In The Absence Of Telomere Shortening

2021-05-05

Abstract excerpt

<h4>SUMMARY</h4> Oxidative stress is a primary cause of cellular senescence and contributes to the pathogenesis of numerous human diseases. Oxidative damage to telomeric DNA is proposed to trigger premature senescence by accelerating telomere shortening. Here we tested this model directly using a precision tool to produce the common base lesion 8-oxo-guanine (8oxoG) exclusively at telomeres in human fibroblast an...

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Literature Corpus work: d8c7c575-a0fd-501b-9dc5-ce89c6b4f2fc
DOI: 10.1101/2021.05.05.442662

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