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Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress

19 Nov 2021

Abstract excerpt

Telomeres are protective nucleoprotein structures that cap linear chromosome ends and safeguard genome stability. Progressive telomere shortening at each somatic cell division eventually leads to critically short and dysfunctional telomeres, which can contribute to either cellular senescence and aging, or tumorigenesis. Human reproductive cells, some stem cells, and most cancer cells, express the enzyme...

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PMID: 34869348
DOI: 10.3389/fcell.2021.758402

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