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Not breathing is not an option: How to deal with oxidative DNA damage

22 Sept 2017

Abstract excerpt

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been implicated in the pathogenesis of a wide variety of diseases, including cancer and neurodegeneration. 7,8-dihydro-8oxo-deoxyGuanine (8-oxo-G) is one of the best characterised oxidative DNA lesions, and it can give rise to point mutations due to its miscoding potential that instructs most DNA polymerases (Pols) to...

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PMID: 28963982
DOI: 10.1016/j.dnarep.2017.09.007

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