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Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening

30 Jun 2022

Abstract excerpt

Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of numerous human diseases. Oxidative damage to telomeric DNA has been proposed to cause premature senescence by accelerating telomere shortening. Here, we tested this model directly using a precision chemoptogenetic tool to produce the common lesion 8-oxo-guanine (8oxoG) exclusively at telomeres in human fibroblasts and...

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Share to DNA Repair Mechanisms
Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 35773409
DOI: 10.1038/s41594-022-00790-y

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