Article
Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei.
Annals of the New York Academy of Sciences - 1 Apr 2004
Nakabeppu Yusaku, Tsuchimoto Daisuke, Ichinoe Akimasa, Ohno Mizuki, Ide Yasuhito, Hirano Seiki, Yoshimura Daisuke, Tominaga Yohei, Furuichi Masato, Sakumi Kunihiko
Abstract excerpt
In mammalian cells, more than one genome in a single cell has to be maintained throughout the entire life of the cell, namely, one in the nucleus and the other in the mitochondria. The genomes and their precursor nucleotides are highly exposed to reactive oxygen species, which are inevitably generated as a result of the respiratory function in mitochondria. To counteract such oxidative damage in nucleic acids,...
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