Article

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates Methotrexate anticancer effects

2020-08-24

Abstract excerpt

<title>Abstract</title> <p>Background: The most common oxidative DNA lesion is 8-oxoguanine (8-oxoG) which is mainly recognized and excised by the glycosylase OGG1, initiating the Base Excision Repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress which disrupts telomere homeostasis triggering genome instability. <h4>Methods:</h4> We used U2OS OGG1-GFP osteosarcoma cell line to study the...

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Literature Corpus work: ecc43b83-a1e2-5174-ad9e-3a7e52026102
DOI: 10.21203/rs.3.rs-57290/v2

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