Article

Altered basal lipid metabolism underlies the functional impairment of naive CD8 <sup>+</sup> T cells in elderly humans

2020-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered antigens. The mechanisms that underlie this phenomenon have nonetheless remained unclear. <h4>Methods</h4> Biochemical and functional properties of naive CD8 + T cells were characterized and compared be...

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Literature Corpus work: 1fbdd228-0932-5534-a9a9-b3aa35e034e5
DOI: 10.1101/2020.09.24.311704

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