Article

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

2026-04-06

Abstract excerpt

As solid tumors progress, the tumor microenvironment (TME) becomes increasingly immunosuppressive, impairing cytotoxic T-cell activity and limiting the efficacy of the immune checkpoint blockade. However, the mechanistic drivers of this immunosuppression remain poorly understood. Here, we identify a tumor-derived lipid–neutrophil–adenosine axis as a critical regulator of immune suppression in advanced colorectal c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e438517d-3f22-5cae-bf9c-8047e9a17538
DOI: 10.64898/2026.04.02.716169

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosineDOI 10.64898/2026.04.02.716169Read

The Inhibitory Effect of Adenosine on Tumor Adaptive Immunity and Intervention StrategiesSemantic proximity Read

Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forwardSemantic proximity Read

Immune cell metabolism in cancer drug resistance: Advances in target discovery and clinical translationSemantic proximity Read

AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRASG12C mutation colorectal cancer liver metastasis.Semantic proximity Read

The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?Semantic proximity Read

Polarization of Tumor Cells and Tumor‐Associated Macrophages: Molecular Mechanisms and Therapeutic TargetsSemantic proximity Read

Shaping immune landscape of colorectal cancer by cholesterol metabolitesSemantic proximity Read

Unmasking the Many Faces of Tumor-Associated Neutrophils and Macrophages: Considerations for Targeting Innate Immune Cells in CancerSemantic proximity Read

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal CancerSemantic proximity Read

Tuning the Tumor Myeloid Microenvironment to Fight CancerSemantic proximity Read

Decoding molecular programs that define macrophage responses to tumor-derived cuesSemantic proximity Read

Acetoacetate suppresses colon cancer via an MR1-MAIT axisSemantic proximity Read