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Fatty Acid Oxidation Promotes Apoptotic Resistance and Proinflammatory Phenotype of CD4+ Tissue-resident Memory T cells in Crohn's Disease.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2024

Liang Guanzhan, Huang Junfeng, Chen Jing, Wen Xiaofeng, Li Ruibing, Xie Hanlin, Zhang Zongjin, Chen Zexian, Chen Yongle, Xian Zhenyu, He Xiaowen, Ke Jia, Lian Lei, Lan Ping, Wu Xianrui, Hu Tuo

Abstract excerpt

BACKGROUND & AIMS: As the most abundant memory T cells and major source of tumor necrosis factor α in the intestinal mucosa of Crohn's disease (CD) patients, CD4+ tissue-resident memory T (TRM) cells play a critical role in CD pathogenesis. We investigated the role of metabolic reprogramming in the regulation of proinflammatory and apoptosis-resistant phenotype for CD4+ TRM cells. METHODS: CD4+ TRM cells were...

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Identifiers

PMID: 38423357
DOI: 10.1016/j.jcmgh.2024.02.014
PMCID: PMC11026735

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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