Article
Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition.
Neurobiology of aging - 1 Nov 2020
Burnham Samantha C, Laws Simon M, Budgeon Charley A, Doré Vincent, Porter Tenielle, Bourgeat Pierrick, Buckley Rachel F, Murray Kevin, Ellis Kathryn A, Turlach Berwin A, Salvado Olivier, Ames David, Martins Ralph N, Rentz Dorene, Masters Colin L, Rowe Christopher C, Villemagne Victor L
Abstract excerpt
Neocortical Aβ-amyloid deposition, one of the hallmark pathologic features of Alzheimer's disease (AD), begins decades prior to the presence of clinical symptoms. As clinical trials move to secondary and even primary prevention, understanding the rates of neocortical Aβ-amyloid deposition and the age at which Aβ-amyloid deposition becomes abnormal is crucial for optimizing the timing of these trials. As APOE-ε4...
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