Article

Neurofilament light protein as a blood biomarker for Huntington’s disease in children

2021-02-04

Abstract excerpt

Juvenile-onset Huntington’s disease (JoHD) is a rare, particularly devastating form of Huntington’s Disease (HD) for which clinical diagnosis is challenging and robust outcome measures are lacking. Neurofilament light protein (NfL) in plasma has emerged as a prognostic biomarker for adult-onset HD. We report that plasma NfL is elevated in JoHD and premanifest HD mutation-carrying children. Quantifying plasma NfL m...

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Literature Corpus work: 9a8f8256-e9b0-5fda-83c3-7f390b37d788
DOI: 10.1101/2021.02.02.21251000

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