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Neurofilament light chain: a biomarker at the crossroads of clarity and confusion for gene-directed therapies

1 Nov 2024

Abstract excerpt

Neurofilament light chain (NfL) is a promising biomarker for neurodegenerative diseases, measurable in both CSF and blood upon neuroaxonal damage. While CSF analysis was traditionally used, blood-based assays now offer a less invasive alternative. NfL levels correlate with disease severity and progression in conditions like Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis and Huntington's...

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PMID: 39545606
DOI: 10.1080/17582024.2024.2421738

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