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Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease

16 Dec 2020

Abstract excerpt

The longitudinal dynamics of the most promising biofluid biomarker candidates for Huntington's disease (HD)-mutant huntingtin (mHTT) and neurofilament light (NfL)-are incompletely defined. Characterizing changes in these candidates during disease progression could increase our understanding of disease pathophysiology and help the identification of effective therapies. In an 80-participant cohort over 24 months,...

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PMID: 33328328
DOI: 10.1126/scitranslmed.abc2888

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