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Plasma neurofilament light chain predicts cerebellar atrophy and clinical progression in spinocerebellar ataxia

23 Feb 2021

Abstract excerpt

Neurofilament light chain (NfL) is a marker of brain atrophy and predictor of disease progression in rare diseases such as Huntington Disease, but also in more common neurological disorders such as Alzheimer's disease. The aim of this study was to measure NfL longitudinally in autosomal dominant spinocerebellar ataxias (SCAs) and establish correlation with clinical and imaging parameters. We enrolled 62...

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PMID: 33636389
DOI: 10.1016/j.nbd.2021.105311

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