Article
Tau or neurofilament light-Which is the more suitable biomarker for Huntington's disease?
PloS one - 1 Jan 2017
Niemelä Valter, Landtblom Anne-Marie, Blennow Kaj, Sundblom Jimmy
Abstract excerpt
INTRODUCTION: Previous studies have suggested cerebrospinal fluid (CSF) levels of neurofilament light (NFL) and total tau are elevated in Huntington's disease (HD) and may be used as markers of disease stage. Biomarkers are needed due to the slow disease progression and the limitations of clinical assessment. This study aims to validate the role of NFL and tau as biomarkers in HD. METHODS: CSF was obtained from a...
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