Article

Plasma neurofilament light levels show elevation prior to diagnosis of sporadic motor neuron disease in the UK Biobank cohort

2023-03-01

Abstract excerpt

<h4>Objective</h4> Motor neuron disease (MND) is a debilitating neurodegenerative disease with profound unmet need. In pre-symptomatic mutation carriers, elevations in neurofilament light (NfL) precede symptom onset, however, the presence and timing of elevation is much more difficult to study in sporadic cases. <h4>Methods</h4> Using the UK Biobank cohort, we tested whether plasma NfL predicted risk of diagnosis...

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Literature Corpus work: 1c0ed557-ac0e-55f8-a8d1-1c6dcd0def9c
DOI: 10.1101/2023.02.27.23286529

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