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Article

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease.

Science translational medicine - 12 Sept 2018

Byrne Lauren M, Rodrigues Filipe B, Johnson Eileanor B, Wijeratne Peter A, De Vita Enrico, Alexander Daniel C, Palermo Giuseppe, Czech Christian, Schobel Scott, Scahill Rachael I, Heslegrave Amanda, Zetterberg Henrik, Wild Edward J

Abstract excerpt

Huntington's disease (HD) is a genetic progressive neurodegenerative disorder, caused by a mutation in the HTT gene, for which there is currently no cure. The identification of sensitive indicators of disease progression and therapeutic outcome could help the development of effective strategies for treating HD. We assessed mutant huntingtin (mHTT) and neurofilament light (NfL) protein concentrations in...

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PMID: 30209243
DOI: 10.1126/scitranslmed.aat7108

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