Simulating a <i>for-loop</i> in the human genome: Design and evaluation of recombinase genetic programs that count to three

Abstract excerpt

<h4>Summary</h4> Pluripotent cells specialize into numerous cell types by receiving external signals, making fate decisions, and executing differentiation functions – a paradigm similar to computer algorithms. While advances in biosensor design have enabled cells to respond to diverse stimuli, the ability to maintain a synthetic memory of the cell’s experiences that then informs its behaviors remains elusive. Her...

Topics

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• Carcinogenesis
• CRISPR-Associated Protein 9
• CRISPR-Cas Systems
• Gene Editing
• Gene Regulatory Networks
• Genetic Engineering
• RNA, Guide, CRISPR-Cas Systems
• Transposases

Identifiers and source

Literature Corpus work

9a8ccb52-3854-5c82-8025-d77b90851dd4

DOI

10.1101/2025.08.04.668540