Article

Discrete-to-analog signal conversion in human pluripotent stem cells

2021-11-06

Abstract excerpt

During development, state transitions are coordinated through changes in the identity of molecular regulators in a cell state- and dose specific manner. The ability to rationally engineer such functions in human pluripotent stem cells (hPSC) will enable numerous applications in regenerative medicine. Herein we report the generation of synthetic gene circuits that can detect a discrete cell state, and upon state de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 047c6342-0cdd-55c5-ab7a-73d3b2043838
DOI: 10.1101/2021.11.05.467377

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discrete-to-analog signal conversion in human pluripotent stem cellsDOI 10.1101/2021.11.05.467377Read

Programmable Organoids and the Emergence of Engineered Genetic and Epigenetic Circuitry in Human DevelopmentSemantic proximity Read

Programmable eukaryotic protein expression with RNA sensorsSemantic proximity Read

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cellsSemantic proximity Read

Synthetic gene circuits that selectively target RAS-driven cancersSemantic proximity Read

Predictive control of human pancreatic cell fate using a digital model of <i>in vitro</i> differentiationSemantic proximity Read

Modular and programmable RNA sensing using ADAR editing in living cellsSemantic proximity Read

Multidimensional control of therapeutic human cell function with synthetic gene circuitsSemantic proximity Read

Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuliSemantic proximity Read

FAST-STEM: A human pluripotent stem cell engineering toolkit for rapid design-build-test-learn development of human cell-based therapeutic devicesSemantic proximity Read

Simulating a <i>for-loop</i> in the human genome: Design and evaluation of recombinase genetic programs that count to threeSemantic proximity Read

Synthetic gene circuits that selectively target RAS-driven cancers.Semantic proximity Read

Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement <i>via</i> Single-Cell GenomicsSemantic proximity Read