Article

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes

2022-11-04

Abstract excerpt

Descriptive data are rapidly expanding in biomedical research. Instead, functional validation methods with sufficient complexity remain underdeveloped. Transcriptional reporters allow experimental characterization and manipulation of developmental and disease cell states, but their design lacks flexibility. Here, we report logical design of synthetic cis -regulatory DNA(LSD), a computational framework leveraging...

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Literature Corpus work: af6fdd4d-1b10-5cb1-a1b9-72031543c371
DOI: 10.1101/2022.11.04.515171

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