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Direct readout of neural stem cell transgenesis with an integration-coupled gene expression switch

2019-11-08

Abstract excerpt

<h4>SUMMARY</h4> Stable genomic integration of exogenous transgenes is critical for neurodevelopmental and neural stem cell studies. Despite the emergence of tools driving genomic insertion at high rates with DNA vectors, transgenesis procedures remain fundamentally hindered by the impossibility to distinguish integrated transgenes from residual episomes. Here, we introduce a novel genetic switch termed iOn that...

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Literature Corpus work
7ec3ea3d-a954-54c2-ac70-36391695ae30
DOI
10.1101/834424
Open publication

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Direct readout of neural stem cell transgenesis with an integration-coupled gene expression switchDOI 10.1101/834424
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