Article

Ccn2 deletion predisposes to aortic aneurysm formation and death in mice which is partially reduced by mineralocorticoid receptor antagonist treatment

2021-07-04

Abstract excerpt

<h4>Background: </h4> and Purpose: Cellular Communication Network Factor 2 (CCN2) is a matricellular protein normally present in the vascular wall but overexpressed in several cardiovascular diseases. CCN2 has been proposed as a downstream mediator of profibrotic actions of Transforming Growth Factor (TGF)-β and Angiotensin II (Ang II). However, its direct role in cardiovascular diseases is not completely understo...

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Literature Corpus work: 9a70521a-7296-5d96-a51b-c375af7001cb
DOI: 10.22541/au.162539389.90915406/v1

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